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发育生物学和干细胞

发育生物学和干细胞

发育生物学研究专注于胚胎发育和干细胞中的组织的生长和组织,这些干细胞可维持组织和修复伤口。这些机制通过对包括 Wnt、Hedgehog、Hippo、Notch 和 TGF-beta 在内的信号通路进行编排来调节。当这些通路被异常调节时,它可能导致癌症的起始、生长和转移。癌症干细胞(CSC)被认为参与肿瘤发育、细胞增殖、转移和对化疗和放射疗法的耐药性。研究 CSC 可以深入了解癌症机制和新型疗法的开发。Cell Signaling Technology (CST) 提供广泛的经验证产品选择,以探索正常发育、癌症进展以及其他退行性疾病的基础核心发育信号通路和基本机制。

发育生物学信号转导

Development and cellular activities are regulated by a dynamic and intricate network of pathways and mechanisms coordinated through cell signaling, such as, the TGF-, Hippo, and Wnt/-catenin pathways. CST has a comprehensive selection of products to elucidate the signaling pathways responsible for the development of complex physiological systems and cancer pathogenesis.

转录因子

Transcription factors are responsible for regulating gene expression, thereby affecting regulation and differentiation of stem cells, development, and tissue formation. Our diverse catalog of antibodies will enable the understanding of transcription factor activity and their role in regulating cellular development.

干细胞标记物、发育与分化研究

Understanding cell differentiation processes, in addition to the regulation of stem cell pluripotency and self-renewal, is important for understanding developmental disorders, and other related diseases, such as cancer and diabetes. CST offers a diverse catalog of products to detect and visualize specific markers of stem cell populations and verify differentiation status through techniques such as immunocytochemistry.

多能性和分化的表观遗传调节

By activating or repressing gene expression, epigenetic modifications are important to maintain the pluripotency and differentiation potential of stem cells. CST provides a comprehensive selection of antibodies to investigate epigenetic regulation and changes that impact phenotype and cell structure.

生长因子

Growth factors direct stem cell development and differentiation towards distinct cell lineages. CST offers high-quality antibodies for the investigation and characterization of the cooperative actions of growth factors in differentiation and proliferation.

发育生物学

CST offers rigorously validated ELISA assay kits to measure the activity of signaling pathways involved in normal development and disease.

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