NKX3-1 Antibodies

Target Information

Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. Belongs to the NK-3 homeobox family. Highly expressed in the prostate and, at a lower level, in the testis. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names