HPF1 Antibodies
Target Information
Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP2 and is able to change amino acid specificity toward serine. Promotes histone serine ADP-ribosylation in response to DNA damage, limiting DNA damage-induced PARP1 hyper-automodification, and ensuring genome stability. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity on PARP1. Belongs to the HPF1 family. Note: This description may include information from UniProtKB.
Alternate Names
C4orf27; FLJ20534; FLJ33423; FLJ42042; Histone PARylation factor 1; HPF1; LOC54969; UPF0609 protein C4orf27HPF1 Antibody Products
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