ZBTB46 (F6Z3F) Rabbit Monoclonal Antibody #72742

Zinc finger and BTB domain-containing protein 46 (ZBTB46) is a member of the broad complex zinc finger protein family, which plays a critical role in transcriptional regulation of immune response, tumor microenvironment, and hematopoietic differentiation (1-3). ZBTB46 is often expressed in dendritic cells (DCs) and their committed progenitors, and is used as a marker to distinguish them from other immune cell types (3,4). ZBTB46 has been shown to act as a transcriptional repressor in these cell types, maintaining a homeostatic steady state; however, it was shown to be non-essential for DC development (3,8). ZBTB46 is also expressed in quiescent endothelial cells and was shown to inhibit cell proliferation (3,4). Recent work has focused on the role of ZBTB46 in tumors. In breast cancer, ZBTB46 was shown to upregulate a long non-coding RNA (lncRNA) that can control breast cancer progression by manipulating tumor immune response (5). A fusion gene consisting of ZBTB46 and WFDC13 is a novel therapeutic target candidate in high-grade serous ovarian carcinoma (6). ZBTB46 is highly expressed and promotes upregulation of inflammation response and neuroendocrine differentiation genes in prostate cancer (7).