YAP/TAZ Transcriptional Targets Antibody Sampler Kit #56674
Product Information
Kit Usage Information
Protocols
- 2808: Western Blotting, Immunoprecipitation (Magnetic), Immunohistochemistry (Paraffin), Immunofluorescence, Flow
- 7074: Western Blotting
- 8661: Western Blotting, Immunoprecipitation (Agarose), Immunohistochemistry (Paraffin), Immunofluorescence, Flow
- 12255: Western Blotting, Immunoprecipitation (Magnetic), Immunofluorescence
- 13295: Western Blotting, Immunoprecipitation (Magnetic)
- 14479: Western Blotting, Immunofluorescence*, Flow
- 25864: Western Blotting, Immunoprecipitation (Magnetic)
- 73663: Western Blotting
- 86641: Western Blotting, Immunofluorescence
Product Description
The YAP/TAZ Transcriptional Targets Antibody Sampler Kit provides an economical means of detecting proteins whose transcription is subject to regulation by the transcriptional co-activators YAP and/or TAZ. The kit provides enough antibody to perform two western blot experiments with each primary antibody.
Background
YAP and TAZ (WWTR1) are transcriptional co-activators that play a central role in the Hippo Signaling pathway that regulates cell, tissue and organ growth. Under growth conditions, YAP and TAZ are translocated to the nucleus, where they interact with DNA-binding transcription factors (e.g., Transcriptional Enhanced Activation Domain [TEAD] proteins) to regulate the expression of genes that control fundamental aspects of cell function, such as proliferation and cell survival (1). A number of genes have been experimentally confirmed as targets of transcriptional regulation by YAP and TAZ. These include the extracellular matrix proteins CTGF, CYR61, and integrin β2 (2-4), the inhibitor of apoptosis protein (IAP) survivin (5), the mechano-sensitive nuclear envelope protein Lamin B2 (6), and the oncogenic receptor tyrosine kinase Axl (7).
- Holden, J.K. and Cunningham, C.N. (2018) Cancers (Basel) 10, .
- Zhang, H. et al. (2009) J Biol Chem 284, 13355-62.
- Chan, S.W. et al. (2011) J Biol Chem 286, 7018-26.
- Chan, S.W. et al. (2011) Oncogene 30, 600-10.
- Zhang, W. et al. (2015) Cancer Res 75, 4450-7.
- Zanconato, F. et al. (2015) Nat Cell Biol 17, 1218-27.
- Cui, Z.L. et al. Int J Immunopathol Pharmacol 25, 989-1001.
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