Name: XRCC2 (E7M8Y) Rabbit Monoclonal Antibody
Price: 371.00 USD
Availability: InStock

Filter:

WB
IP

Product Specifications

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	29
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting
IP-Immunoprecipitation

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Immunoprecipitation	1:200

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

XRCC2 (E7M8Y) Rabbit Monoclonal Antibody recognizes endogenous levels of total XRCC2 protein. By western blot, this antibody detects a 40 kDa band of unknown origin.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys267 of human XRCC2 protein.

Background

XRCC2 (X-ray repair cross-complementing protein 2) is one of five RAD51 paralogs that form two distinct complexes, BCDX2 (RAD51B, RAD51C, RAD51D, and XRCC2) and CX3 (RAD51C and XRCC3) (1). Along with RAD51, these complexes are crucial in the repair of DNA double-strand breaks through homologous recombination (2) and in response to DNA replication stress (3,4). XRCC2 expression and genetic polymorphisms are associated with the risk and prognosis of human cancer (5-10). In non-small cell lung cancer (NSCLC) XRCC2 reduces sensitivity to chemotherapy and radiation treatment (11).

Alternate Names

DKFZp781P0919; DNA repair protein XRCC2; epididymis secretory sperm binding protein; FANCU; RAD51-like; X-ray repair complementing defective repair in Chinese hamster cells 2; X-ray repair cross complementing 2; X-ray repair cross complementing protein 2; X-ray repair cross-complementing protein 2; X-ray repair, complementing defective, repair in Chinese hamster; XRCC2

Database Links

UniProt ID: O43543

Entrez-Gene Id: 7516

限制使用

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For Research Use Only. Not for Use in Diagnostic Procedures.

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XRCC2 (E7M8Y) Rabbit Monoclonal Antibody #86714