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  3. xCT/SLC7A11 Antibody

xCT/SLC7A11 Antibody #98051

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  • WB

    Product Specifications

    REACTIVITY M
    SENSITIVITY Endogenous
    MW (kDa) 35
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    实验步骤

    Specificity / Sensitivity

    xCT/SLC7A11 Antibody recognizes endogenous levels of total mouse xCT/SLC7A11 protein.

    Species Reactivity:

    Mouse

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro25 of mouse xCT/SLC7A11 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    The Xc- cystine/glutamate antiporter consists of a light chain subunit (xCT/SLC7A11) that confers substrate specificity and a glycosylated heavy chain subunit (4F2hc/SLC3A2) located on the cell surface (1,2). The heterodimeric amino acid transport system Xc- provides selective import of cystine into cells in exchange for glutamate and regulates intracellular glutathione (GSH) levels, essential for cellular protection from oxidative stress (3). Research studies have shown that xCT expression increases in various tumors, including gliomas, and have implicated xCT in GSH-mediated anticancer drug resistance (4,5). Researchers have found that xCT provides neuroprotection by enhancing glutathione export from non-neuronal cells (6). Moreover, investigators identified xCT as the fusion-entry receptor for Kaposi's sarcoma-associated herpesvirus (7).

    Alternate Names

    9930009M05Rik; AI451155; amino acid transport system xc cysteine/glutamate transporter; Amino acid transport system xc-; cysteine/glutamate transporter; Cystine/glutamate transporter; OTTMUSP00000023507; Slc7a11; sodium independent anionic amino acid transport system; solute carrier family 7 (cationic amino acid transporter, y+ system), member 11; Solute carrier family 7 member 11; sut; xCT

    Database Links

    UniProt ID: Q9WTR6


    Entrez-Gene Id: 26570


    限制使用

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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