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  3. VRK3 Antibody

VRK3 Antibody #3260

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  • WB

    Product Specifications

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 54
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    实验步骤

    Specificity / Sensitivity

    VRK3 Antibody detects endogenous levels of total VRK3 protein.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to human VRK3. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    The vaccinia-related kinase (VRK) proteins are a new group of Ser/Thr kinases in the human kinome. This mammalian kinase family comprises three members, VRK1, VRK2, and VRK3 (1-3). The VRK1 has autophosphorylation activity and phosphorylates several transcription factors, including p53 (4), ATF2 (5), and c-Jun (6). VRK2 is associated with the endoplasmic reticulum (7). VRK3 suppresses Erk activity through direct interaction and activation of the MAP kinase phosphatase VHR (8). Further functional and structural analysis of VRK proteins will elucidate important new aspects of cell regulation.

    Alternate Names

    Inactive serine/threonine-protein kinase VRK3; Serine/threonine-protein kinase VRK3; Serine/threonine-protein pseudokinase VRK3; vaccinia related kinase 3; Vaccinia-related kinase 3; VRK serine/threonine kinase 3; VRK3

    Database Links

    UniProt ID: Q8IV63


    Entrez-Gene Id: 51231


    限制使用

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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