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  3. UGT Antibody

UGT Antibody #4371

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  • WB

    Product Specifications

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 55-60
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    UGT Antibody detects endogenous levels of proteins from the UGT1A subfamily.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of the UGT1A subfamily. Antibodies were purified by protein A and peptide affinity chromatography.

    Background

    Glucuronidation is a major pathway that enhances the elimination of lipophilic xenobiotics and endobiotics to more more water soluble compounds for excretion (1,2). The UDP-glucuronosyltransferase (UGT) superfamily catalyzes the glucuronidation of the glycosyl group of a nucleotide sugar to a variety of endogenous and exogenous compounds. Over 100 UGT mammalian gene products have been described and have been divided into subfamilies based on sequence identities (3). The UGT1 subfamily consists of a number of gene products resulting from alternative splicing. These UGT products can differ in tissue expression and substrate specificity. Also, marked differences in the individual expression of UGT isoforms can account for differences in drug metabolism.

    Alternate Names

    BILIQTL1; bilirubin UDP-glucuronosyltranserase; bilirubin UDP-glucuronosyltransferase 1-1; bilirubin UDP-glucuronosyltransferase isozyme 1; bilirubin UDP-glucuronosyltransferase isozyme 2; Bilirubin-specific UDPGT isozyme 1; Bilirubin-specific UDPGT isozyme 2; GNT1; HLUGP; HLUGP1; HLUGP4; hUG-BR1; hUG-BR2; lugP4; MGC29860; Phenol-metabolizing UDP-glucuronosyltransferase; UD11; UD110; UD13; UD14; UD15; UD16; UD17; UD18; UD19; UDP glucuronosyltransferase 1 family, polypeptide A1; UDP glucuronosyltransferase 1 family, polypeptide A10; UDP glucuronosyltransferase 1 family, polypeptide A3; UDP glucuronosyltransferase 1 family, polypeptide A4; UDP glucuronosyltransferase 1 family, polypeptide A5; UDP glucuronosyltransferase 1 family, polypeptide A6; UDP glucuronosyltransferase 1 family, polypeptide A7; UDP glucuronosyltransferase 1 family, polypeptide A8; UDP glucuronosyltransferase 1 family, polypeptide A9; UDP glucuronosyltransferase 1A1; UDP glucuronosyltransferase 1A3; UDP glucuronosyltransferase family 1 member A1; UDP glucuronosyltransferase family 1 member A10; UDP glucuronosyltransferase family 1 member A3; UDP glucuronosyltransferase family 1 member A4; UDP glucuronosyltransferase family 1 member A5; UDP glucuronosyltransferase family 1 member A6; UDP glucuronosyltransferase family 1 member A7; UDP glucuronosyltransferase family 1 member A8; UDP glucuronosyltransferase family 1 member A9; UDP glycosyltransferase 1 family, polypeptide A1; UDP glycosyltransferase 1 family, polypeptide A10; UDP glycosyltransferase 1 family, polypeptide A3; UDP glycosyltransferase 1 family, polypeptide A4; UDP glycosyltransferase 1 family, polypeptide A5; UDP glycosyltransferase 1 family, polypeptide A6; UDP glycosyltransferase 1 family, polypeptide A7; UDP glycosyltransferase 1 family, polypeptide A8; UDP glycosyltransferase 1 family, polypeptide A9; UDP-glucuronosyltransferase 1 family polypeptide A3s; UDP-glucuronosyltransferase 1 family polypeptide A4s; UDP-glucuronosyltransferase 1 family polypeptide A5s; UDP-glucuronosyltransferase 1 family polypeptide A6s; UDP-glucuronosyltransferase 1 family polypeptide A7s; UDP-glucuronosyltransferase 1 family polypeptide A8s; UDP-glucuronosyltransferase 1 family polypeptide A9s; UDP-glucuronosyltransferase 1-1; UDP-glucuronosyltransferase 1-10; UDP-glucuronosyltransferase 1-3; UDP-glucuronosyltransferase 1-4; UDP-glucuronosyltransferase 1-5; UDP-glucuronosyltransferase 1-6; UDP-glucuronosyltransferase 1-7; UDP-glucuronosyltransferase 1-8; UDP-glucuronosyltransferase 1-9; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1-C; UDP-glucuronosyltransferase 1-D; UDP-glucuronosyltransferase 1-E; UDP-glucuronosyltransferase 1-F; UDP-glucuronosyltransferase 1-G; UDP-glucuronosyltransferase 1-H; UDP-glucuronosyltransferase 1-I; UDP-glucuronosyltransferase 1-J; UDP-glucuronosyltransferase 1A; UDP-glucuronosyltransferase 1A isoform 1; UDP-glucuronosyltransferase 1A isoform 3; UDP-glucuronosyltransferase 1A1; UDP-glucuronosyltransferase 1A10; UDP-glucuronosyltransferase 1A3; UDP-glucuronosyltransferase 1A4; UDP-glucuronosyltransferase 1A5; UDP-glucuronosyltransferase 1A6; UDP-glucuronosyltransferase 1A7; UDP-glucuronosyltransferase 1A8; UDP-glucuronosyltransferase 1A9; UDPGT; UDPGT 1-1; UDPGT 1-10; UDPGT 1-3; UDPGT 1-4; UDPGT 1-5; UDPGT 1-6; UDPGT 1-7; UDPGT 1-8; UDPGT 1-9; UGT-1A; UGT-1C; UGT-1D; UGT-1E; UGT-1F; UGT-1G; UGT-1H; UGT-1I; UGT-1J; UGT1; UGT1-01; UGT1-03; UGT1-04; UGT1-05; UGT1-06; UGT1-07; UGT1-08; UGT1-09; UGT1-10; UGT1-9; UGT1.1; UGT1.10; UGT1.3; UGT1.4; UGT1.5; UGT1.6; UGT1.7; UGT1.8; UGT1.9; UGT1A; UGT1A1; UGT1A10; UGT1A3; UGT1A3S; UGT1A4; UGT1A4S; UGT1A5; UGT1A6; Ugt1a6a; UGT1A6S; UGT1A7; UGT1A8; UGT1A8S; UGT1A9; UGT1A9S; UGT1AI; UGT1C; UGT1D; UGT1E; UGT1F; UGT1G; UGT1H; UGT1I; UGT1J

    Database Links

    UniProt ID: Q9HAW8 , O60656 , P35503 , P22309 , P35504 , P22310 , Q9HAW7 , Q9HAW9 , P19224


    Entrez-Gene Id: 54575 , 54600 , 54659 , 54658 , 54579 , 54657 , 54577 , 54576 , 54578


    限制使用

    除非 CST 的合法授书代表以书面形式书行明确同意，否书以下条款适用于 CST、其关书方或分书商提供的书品。 任何书充本条款或与本条款不同的客书条款和条件，除非书 CST 的合法授书代表以书面形式书独接受， 否书均被拒书，并且无效。

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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