Cell Signaling Technology Logo - Extra Large
查看特别推荐 >>
  1. Products /
  2. Primary Antibodies /
  3. UAP1 (F5K2U) Rabbit Monoclonal Antibody
Trial Size Available Flag
Recombinant Flag
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

UAP1 (F5K2U) Rabbit Monoclonal Antibody #51786

Filter:
  • WB

    Product Specifications

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 62, 59
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Simple Western™ 1:50 - 1:250

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    实验步骤

    Specificity / Sensitivity

    UAP1 (F5K2U) Rabbit Monoclonal Antibody recognizes endogenous levels of total UAP1 protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human UAP1 protein.

    Background

    UDP-N-acetylglucosamine pyrophosphorylase 1 (UAP1) is a metabolic enzyme that plays a key role in the hexosamine biosynthesis pathway (HBP). UAP1 catalyzes the final step in the pathway by converting uridine triphosphate (UTP) and GlcNAc-1-phosphate to UDP-GlcNAc, a nucleotide sugar (1). UDP-GlcNAc is further utilized as a substrate for multiple glycosylation reactions, including O-GlcNAcylation of target proteins (2). HBP dysfunction has been linked to various cancers, potentially due to elevated O-GlcNAcylation levels affecting signaling pathways (3). UAP1 expression levels are particularly elevated in prostate cancer, and knockdown of UAP1 has been found to reduce cell growth and viability in prostate cancer cells (4-6). Altered UAP1 expression levels have also been linked to other cancers, such as osteosarcoma and breast cancer (7,8).

    Alternate Names

    AGX; AGX-1; AGX-2; AGX1; AGX2; Antigen X; SPAG2; sperm associated antigen 2; Sperm-associated antigen 2; testis tissue sperm-binding protein Li 37a; UAP1; UDP-N-acetylgalactosamine pyrophosphorylase; UDP-N-acetylglucosamine diphosphorylase 1; UDP-N-acetylglucosamine pyrophosphorylase; UDP-N-acetylglucosamine pyrophosphorylase 1; UDP-N-acetylhexosamine pyrophosphorylase; UDP-N-acetylhexosamine pyrophosphorylase 1; UDP-N-acteylglucosamine pyrophosphorylase 1

    Database Links

    UniProt ID: Q16222


    Entrez-Gene Id: 6675


    限制使用

    除非 CST 的合法授书代表以书面形式书行明确同意，否书以下条款适用于 CST、其关书方或分书商提供的书品。 任何书充本条款或与本条款不同的客书条款和条件，除非书 CST 的合法授书代表以书面形式书独接受， 否书均被拒书，并且无效。

    专品专有“专供研究使用”的专专或专似的专专声明， 且未专得美国食品和专品管理局或其他外国或国内专管机专专专任何用途的批准、准专或专可。客专不得将任何专品用于任何专断或治专目的， 或以任何不符合专专声明的方式使用专品。CST 专售或专可的专品提供专作专最专用专的客专，且专用于研专用途。将专品用于专断、专防或治专目的， 或专专售（专独或作专专成）或其他商专目的而专专专品，均需要 CST 的专独专可。客专：(a) 不得专独或与其他材料专合向任何第三方出售、专可、 出借、捐专或以其他方式专专或提供任何专品，或使用专品制造任何商专专品，(b) 不得复制、修改、逆向工程、反专专、 反专专专品或以其他方式专专专专专品的基专专专或技专，或使用专品开专任何与 CST 的专品或服专专争的专品或服专， (c) 不得更改或专除专品上的任何商专、商品名称、徽专、专利或版专声明或专专，(d) 只能根据 CST 的专品专售条款和任何适用文档使用专品， (e) 专遵守客专与专品一起使用的任何第三方专品或服专的任何专可、服专条款或专似专专

    For Research Use Only. Not for Use in Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.