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  3. TRPS1 Antibody

TRPS1 Antibody #17936

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  • WB

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 160
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    实验步骤

    Specificity / Sensitivity

    TRPS1 Antibody recognizes endogenous levels of total TRPS1 protein.

    Species Reactivity:

    Human

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala39 of human TRPS1 protein. Antibodies are purified by peptide affinity chromatography.

    Background

    TRPS1 is a transcription factor that was initially discovered as being mutated in Tricho-rhino-phalangeal syndrome, a craniofacial and skeletal malformation syndrome (1,2). It was also found to be expressed at higher levels in androgen-dependent prostate cancers, reducing the expression of PSA (3,4). TRPS1 recognizes GATA sequences and represses the activation potential of other GATA factors (5). By repressing STAT3 expression, TRPS1 regulates chondrocyte proliferation and survival (6,7). TRPS1 also can increase the activity of HDAC1 and HDAC4 during mitosis to promote histone deacetylation (8). In addition, TRPS1 binds to the NuRD complex via CHD4 and can repress other key transcription factors such as p63 and estrogen receptor (9-11).

    Alternate Names

    GC79; LGCR; MGC134928; transcriptional repressor GATA binding 1; Tricho-rhino-phalangeal syndrome type I protein; trichorhinophalangeal syndrome I; TRPS1; Zinc finger protein GC79; Zinc finger transcription factor Trps1

    Database Links

    UniProt ID: Q9UHF7


    Entrez-Gene Id: 7227


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    For Research Use Only. Not for Use in Diagnostic Procedures.
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