TRPS1 Antibody #17936
Filter:
- WB
Supporting Data
REACTIVITY | H |
SENSITIVITY | Endogenous |
MW (kDa) | 160 |
SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
Application | Dilution |
---|---|
Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
TRPS1 Antibody recognizes endogenous levels of total TRPS1 protein.
Species Reactivity:
Human
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala39 of human TRPS1 protein. Antibodies are purified by peptide affinity chromatography.
Background
TRPS1 is a transcription factor that was initially discovered as being mutated in Tricho-rhino-phalangeal syndrome, a craniofacial and skeletal malformation syndrome (1,2). It was also found to be expressed at higher levels in androgen-dependent prostate cancers, reducing the expression of PSA (3,4). TRPS1 recognizes GATA sequences and represses the activation potential of other GATA factors (5). By repressing STAT3 expression, TRPS1 regulates chondrocyte proliferation and survival (6,7). TRPS1 also can increase the activity of HDAC1 and HDAC4 during mitosis to promote histone deacetylation (8). In addition, TRPS1 binds to the NuRD complex via CHD4 and can repress other key transcription factors such as p63 and estrogen receptor (9-11).
- Momeni, P. et al. (2000) Nat Genet 24, 71-4.
- Hou, J. et al. (1995) Genomics 29, 87-97.
- Chang, G.T. et al. (1997) Cancer Res 57, 4075-81.
- van den Bemd, G.J. et al. (2003) Biochem Biophys Res Commun 312, 578-84.
- Malik, T.H. et al. (2001) EMBO J 20, 1715-25.
- Suemoto, H. et al. (2007) Dev Biol 312, 572-81.
- Itoh, S. et al. (2008) Genes Cells 13, 355-63.
- Wuelling, M. et al. (2013) Cell Cycle 12, 2219-32.
- Serandour, A.A. et al. (2018) Oncogene 37, 5281-91.
- Witwicki, R.M. et al. (2018) Cell Rep 25, 1255-1267.e5.
- Wang, Y. et al. (2018) Oncogenesis 7, 96.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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