TREM1 (D7D6I) Rabbit Monoclonal Antibody (Flow Specific) #96768

Triggering receptor expressed on myeloid cells 1 (TREM1) is a cell surface receptor found on neutrophils, monocytes, and macrophages, where it plays a critical role in regulating immune responses (1). TREM1 is activated by various extracellular ligands, including PGLYRP1, HMGB1, and eCIRP (CIRBP) (2). Upon activation, TREM1 associates with and induces the phosphorylation of its adaptor protein, DAP12, triggering downstream signaling pathways that drive proinflammatory cytokine production (3).Acting as an inflammatory amplifier, TREM-1 contributes to the pathogenesis of infectious diseases (4), non-infectious tissue damage (5), autoimmune disorders (6), and sepsis (7). In the central nervous system, TREM-1 expression in microglia promotes activation and polarization toward a proinflammatory phenotype, thereby facilitating disease progression (8). In the liver, TREM-1 is expressed on non-parenchymal cells (NPCs), where it stimulates the release of cytokines and chemokines and regulates lipid metabolism and fibrosis (9). Furthermore, TREM-1 promotes cancer cell proliferation, migration, and invasion by modulating tumor-associated inflammation and the microenvironment (10,11). Consequently, targeting TREM-1 represents a promising therapeutic strategy for these diverse inflammatory conditions.