TorsinA (D-M2A8) Mouse Monoclonal Antibody

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Inquiry Info. # 2150

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Product Specifications

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	35
Source/Isotype	Mouse IgG1

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

实验步骤

Specificity / Sensitivity

TorsinA (D-M2A8) Mouse Monoclonal Antibody detects endogenous levels of total torsinA protein. This antibody does not detect TorsinB (Hewett, J. et al., 2004).

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with human recombinant torsinA (aa 51-324).

Background

The neurological condition Dystonia is associated with sustained muscle contractions and abnormal posturing (1). TorsinA, torsinB, torp2A and torp3A belong to the family of ATPases associated with cellular activites (AAA+) and mutations in torsinA cause early onset dystonia (2). TorsinA has been shown to suppress intracellular protein aggregation in C. elegans and possesses chaperon activity. Interestingly, torsinA is highly expressed in dopaminergic neurons and associates with alpha-synuclein in Lewy bodies, which pathologically characterize Parkinson's Disease (3-5).

Alternate Names

AMC5; DQ2; Dystonia 1 protein; dystonia 1, torsion (autosomal dominant; DYT1; TA; TOR1A; TORA; torsin A; torsin A); torsin ATPase 1; Torsin ATPase-1A; Torsin family 1 member A; torsin family 1, member A (torsin A); Torsin-1A

Database Links

UniProt ID: O14656

Entrez-Gene Id: 1861

限制使用

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For Research Use Only. Not for Use in Diagnostic Procedures.

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TorsinA (D-M2A8) Mouse Monoclonal Antibody #2150