TCEB3/Elongin A Antibody

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WB

Inquiry Info. # 3685

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Product Specifications

REACTIVITY	H Mk
SENSITIVITY	Endogenous
MW (kDa)	100
SOURCE	Rabbit

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human
Mk-Monkey

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

实验步骤

Specificity / Sensitivity

TCEB3/Elongin A Antibody recognizes endogenous levels of total TCEB3/Elongin A protein.

Species Reactivity:

Human, Monkey

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human TCEB3/Elongin A protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

The Elongin complex is a heterotrimer composed of TCEB3/Elongin A, Elongin B (TCEB2), and Elongin C (TCEB1) subunits (1-3). The Elongin complex regulates the rate of RNA polymerase II (RNAPII) transcription elongation by releasing the transient pausing of RNAPII at multiple sites along the DNA. TCEB3/Elongin A is the transcriptionally active subunit, while Elongin B and C subunits play a regulatory role (3,4). TCEB3/Elongin A may be required for expression of a subset of cell cycle regulated genes, and embryonic stem (ES) cells lacking TCEB3/Elongin A show abnormalities in cell size, growth, and cell cycle distribution (5). In addition, the Elongin complex has been shown to interact with the cullin family and RING finger proteins Cul5/Rbx2 upon UV-induced DNA damage, removing arrested RNAPII at sites of DNA damage by ubiquitination and degradation as part of an E3 ubiquitin ligase (6).

Alternate Names

EloA; ELOA1; Elongin 110 kDa subunit; elongin A; Elongin-A; FLJ38760; FLJ42849; RNA polymerase II transcription factor SIII subunit A1; SIII; SIII p110; TCEB3; TCEB3A; transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A); transcription elongation factor B alpha subunit; Transcription elongation factor B polypeptide 3; transcription elongation factor B subunit 3

Database Links

UniProt ID: Q14241

Entrez-Gene Id: 6924

限制使用

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For Research Use Only. Not for Use in Diagnostic Procedures.

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TCEB3/Elongin A Antibody #3685