Name: Synaptojanin-2 (F7C1M) Rabbit Monoclonal Antibody
Price: 152.00 USD
Availability: InStock

Filter:

WB

Product Specifications

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	200
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

实验步骤

Specificity / Sensitivity

Synaptojanin-2 (F7C1M) Rabbit Monoclonal Antibody recognizes endogenous levels of total SYNJ2 protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human SYNJ2 protein.

Background

Synaptojanin (SYNJ) is a phosphatidylinositol (PI) phosphatase located on the plasma membrane (1). SYNJ1 is a brain-enriched presynaptic phosphatase involved in synaptic vesicle recycling, clathrin-coated vesicle uncoating at synapse. While SYNJ1 is brain-specific, its paralog SYNJ2 is ubiquitously expressed. SYNJ2 is also abundantly expressed in the synapse and inhibits clathrin-mediated endocytosis (2). The main function of both SYNJ1 and SYNJ2 is to remove the five-position phosphates from PI (3,4,5)-trisphosphate (PIP₃) and PI 4,5-bisphosphate (PIP₂) (3). Genetic variations in SYNJ2 are widely associated with human disease, such as reduced cognitive ability, Alzheimer’s disease (AD), depression, Parkinson’s disease (PD), medulloblastoma, prostate cancer, breast cancer, and lung cancer (4-10).

Alternate Names

inositol phosphate 5'-phosphatase 2; inositol phosphate 5'-phosphatase 2 (synaptojanin 2); inositol polyphosphate-5-phosphatase H; INPP5H; KIAA0348; MGC44422; phosphoinositide 5-phosphatase; Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2; Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 2; synaptojanin 2; Synaptojanin-2; SYNJ2

Database Links

UniProt ID: O15056

Entrez-Gene Id: 8871

限制使用

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For Research Use Only. Not for Use in Diagnostic Procedures.

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Synaptojanin-2 (F7C1M) Rabbit Monoclonal Antibody #58363