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  3. SUN1 (F5R6C) Rabbit Monoclonal Antibody
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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

SUN1 (F5R6C) Rabbit Monoclonal Antibody #71548

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    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 100
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    • IF-Immunofluorescence 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50
    Immunofluorescence (Immunocytochemistry) 1:100

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    实验步骤

    Specificity / Sensitivity

    SUN1 (F5R6C) Rabbit Monoclonal Antibody recognizes endogenous levels of total SUN1 protein. This antibody does not cross-react with SUN2 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala426 of human SUN1 protein.

    Background

    The Sad1 and UNC domain proteins (SUN1 and SUN2) are nuclear envelope-associated proteins with similar C-terminal domains. SUN1 and SUN2 are part of the linker of nucleoskeleton and cytoskeleton (LINC) complex, which spans the nuclear envelope and binds to lamin A, providing key structural support (1-3). Furthermore, SUN1 and SUN2 bind to the Klarsicht, ANC-1, Syne Homology (KASH) domains of various proteins, such as the nespirins, to tether them to the outer nuclear membrane (3,4). While SUN1 and SUN2 have some redundancy, their localization differs slightly, with SUN1 being more concentrated at nuclear pore complexes (5). SUN1 and SUN2 are critical for nuclear positioning in many cellular processes, including muscle and neuronal development, meiosis, and viral response (6-10). SUN proteins have also been shown to be required for mRNA export by interacting with various hnRNP proteins (11).

    Alternate Names

    FLJ12407; KIAA0810; MGC176649; Protein unc-84 homolog A; Sad1 and UNC84 domain containing 1; Sad1 unc-84 domain protein 1; Sad1/unc-84 protein-like 1; SUN domain-containing protein 1; SUN1; unc-84 homolog A; UNC84A

    Database Links

    UniProt ID: O94901


    Entrez-Gene Id: 23353


    限制使用

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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