SRSF2 (F1P3N) Rabbit Monoclonal Antibody #50901

Serine/arginine-rich splicing factor 2 (SRSF2/SFRS2), also known as splicing factor SC35, is a well-studied serine/arginine-rich splicing factor (SR) protein. SR proteins are crucial regulators in precursor RNA splicing, a process associated with maintaining genome stability, regulating mRNA export and stability, and translation (1,2). SRSF2 and other SR proteins harbor an N-terminal RNA recognition motif (RRM) that is involved in sequence-specific RNA binding and a C-terminal arginine/serine-rich (RS) domain that facilitates interactions with other splicing proteins (2-5). Similar to most other SR proteins, SRSF2 is essential for normal development as its germline deletion is embryonically lethal in mice (6,7). Moreover, mutations in the SRSF2 gene are often found in myelodysplasia, with the most common hotspot mutation, a substitution of proline for histidine at position 95, causing altered recognition of exonic splicing enhancers and aberrantly spliced transcripts (8-10). In myeloid malignancies, SRSF2 mutations have been linked to abnormal differentiation of hematopoietic stem and progenitor cells (11).