SRRM2 (F3J1Z) Rabbit Monoclonal Antibody #19700

Nuclear speckles (NS) are distinct biomolecular condensates consisting of nuclear proteins and RNA molecules. Although their exact biological function is not fully understood, NS are believed to function as hubs for mRNA splicing and potentially transcription (1). The splicing factors serine/arginine repetitive matrix protein 2 (SRRM2) and SON are necessary for NS formation (2). SRRM2 and SON undergo phase separation and function as scaffolding proteins, recruiting additional splicing factors and promoting NS assembly (3). In Alzheimer’s disease (AD) and other tauopathies, SRRM2 can become mislocalized from NS to pathological tau aggregates in the cytoplasm, resulting in aberrant splicing (4,5). Loss-of-function (LoF) mutations in SRRM2 have also been associated with neurodevelopmental delay and an increased risk of developing papillary thyroid carcinoma (PTC) (6,7).