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  3. SMAD 1/5/9 Antibody Sampler Kit

SMAD 1/5/9 Antibody Sampler Kit #12656

    Product Information

    Kit Usage Information

    Protocols

    Product Description

    The SMAD1/5/9 Antibody Sampler Kit provides an economical means of detecting target proteins of the BMP signaling pathway. The kit includes enough antibody to perform two western blots with each primary antibody.

    Background

    Transforming growth factor-β (TGF-β) superfamily signaling plays a critical role in the regulation of cell growth, differentiation, and development in a wide range of biological systems. In general, signaling is initiated with ligand-induced oligomerization of serine/ threonine receptor kinases and phosphorylation of the cytoplasmic signaling molecules Smad2 and Smad3 for the TGF-β/activin pathway, or Smad1/5/9 for the bone morphogenetic protein (BMP) pathway. Carboxy-terminal phosphorylation of Smads by activated receptors results in their partnering with the common signaling transducer Smad4, and translocation to the nucleus. Activated Smads regulate diverse biological effects by partnering with transcription factors resulting in cell-state specific modulation of transcription (1-7) .

    Alternate Names

    bmp; bmp signaling; bmp2; bmp4; psmad; psmad1; psmad1/5; psmad1/5/8; psmad15; psmad158; smad; smad1; smad1/5; smad1/5/8; smad15; smad158; smad159; smad4; smad5; smad8; smad9; tgf; tgf beta; tgfb

    Database Links

    UniProt ID: Q99717 , Q15797 , O15198 , Q13485


    Entrez-Gene Id: 4090 , 4086 , 4093 , 4089


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    For Research Use Only. Not for Use in Diagnostic Procedures.
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