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Render Timestamp:
6/1/2026, 8:29:50 PM EDT
6/2/2026, 12:29:50 AM UTC
Commit: 7ed46ecc04b401f23a28df741b5078df405d23e4
XML generation date: 2025-11-12 16:15:04.938
Product last modified at: 2026-03-20T08:05:27.438Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
  1. Products /
  2. Primary Antibodies /
  3. SLIT2 (E8W7Y) Rabbit Monoclonal Antibody
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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

SLIT2 (E8W7Y) Rabbit Monoclonal Antibody #47600

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  • WB

    Product Specifications

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 200
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    实验步骤

    Specificity / Sensitivity

    SLIT2 (E8W7Y) Rabbit Monoclonal Antibody recognizes endogenous levels of total SLIT2 protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln1463 of human SLIT2 protein.

    Background

    SLIT2 is an extracellular matrix-associated SLIT family member that functions as a ligand for roundabout (ROBO) family receptors (1). Activation of ROBO receptors by SLIT2 regulates various biological processes, including promoting cellular senescence via WNT inhibition (2), suppressing migration by enhanced β-catenin/E-cadherin association, regulating actin polymerization (4, 5), and suppressing cell proliferation induced by SDF1 and MCP1 (6, 7). In development, the SLIT-ROBO pathways play important roles in neuronal axon guidance, angiogenesis, and both kidney and mammary gland organogenesis. SLIT2 expression has been reported to suppress cancer cell growth, invasion, and metastasis, suggesting that modulation of SLIT2-ROBO signaling may have therapeutic potential in cancer biology (8, 9).

    Alternate Names

    FLJ14420; SLIL3; slit guidance ligand 2; slit homolog 2 (Drosophila); Slit homolog 2 protein; Slit homolog 2 protein C-product; Slit homolog 2 protein N-product; Slit-2; SLIT2

    Database Links

    UniProt ID: O94813


    Entrez-Gene Id: 9353


    限制使用

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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