SGTA Antibody #3349
Filter:
- WB
Supporting Data
REACTIVITY | H |
SENSITIVITY | Endogenous |
MW (kDa) | 34 |
SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
Application | Dilution |
---|---|
Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
SGTA Antibody detects endogenous levels of total SGTA protein.
Species Reactivity:
Human
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to human SGTA. Antibodies are purified by protein A and peptide affinity chromatography.
Background
SGTA, small glutamine-rich tetratricopeptide repeat-containing protein A, is an ubiquitously expressed co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity (1,2). SGTA is a 34 kDa protein that is rich in glutamine residues at its C terminus and contains three tandemly repeated TPR motifs (3). The TPR domain of SGTA shows sequence similarity to the TPR domains of Hop, CHIP, and TOM70 (4). The TPR domain of SGTA also interacts with HSP90 and was recently found to be a pro-apoptotic factor (5,6).
- Liu, F.H. et al. (1999) J Biol Chem 274, 34425-32.
- Tobaben, S. et al. (2003) J Biol Chem 278, 38376-83.
- Cziepluch, C. et al. (1998) J Virol 72, 4149-56.
- Scheufler, C. et al. (2000) Cell 101, 199-210.
- Liou, S.T. and Wang, C. (2005) Arch Biochem Biophys 435, 253-63.
- Yin, H. et al. (2006) Biochem Biophys Res Commun 343, 1153-8.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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