SerpinB1 (E4W7B) Rabbit Monoclonal Antibody #20407

Serpin family B member 1 (SerpinB1), also known as leukocyte elastase inhibitor or neutrophil elastase inhibitor, regulates inflammation and the innate immune response. SerpinB1 blocks the activity of caspase-1, caspase-4, and caspase-5; the protein does so via suppression of caspase recruitment domain oligomerization and enzymatic activation (1). SerpinB1 is expressed in neutrophils and monocytes, and the protein resides in the cytoplasm due to its lack of a secretory signal sequence (2,3). There, SerpinB1 protects cells from serine proteases that may leak from granules into the cytoplasm, including Cathepsin G, neutrophil elastase, proteinase-3, and Granzyme H (4,5). Despite its lack of a secretory sequence, SerpinB1 was shown to be released from keratinocytes in a caspase-1-dependent manner to upregulate proliferation of pancreatic β cells (6).