Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
Secernin-1 (F6Q7G) Rabbit Monoclonal Antibody #67380
Filter:
- WB
- IP
Product Specifications
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 50 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Simple Western™ | 1:10 - 1:50 |
| Immunoprecipitation | 1:50 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
实验步骤
Specificity / Sensitivity
Secernin-1 (F6Q7G) Rabbit Monoclonal Antibody recognizes endogenous levels of total secernin-1 protein.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro335 of human secernin-1 protein.
Background
Secernin-1, encoded by the gene SCRN1, is a 50 kDa cytosolic protein implicated in a variety of biological functions. Originally discovered as a protein that regulates mast cell exocytosis, secernin-1 has been suggested to play roles in axon growth, endoplasmic reticulum (ER) remodeling, and presynaptic vesicle recycling (1-3). In Alzheimer’s disease (AD), secernin-1 was found to be abundant within amyloid plaques of dystrophic neurites and in neurofibrillary tangles (NFTs). Co-immunoprecipitation of secernin-1 and phosphorylated tau from AD patient brain samples further suggests a direct interaction between these proteins (4,5). Secernin-1 levels were also found to be increased in the cerebrospinal fluid (CSF) of AD patients, correlating with total and phospho-tau levels, suggesting its potential as a diagnostic and prognostic biofluid biomarker (6). Beyond AD, SCRN1 has been identified as a tumor-associated gene, with expression levels implicated in the development and progression of various cancers (7-9).
- Way, G. et al. (2002) Mol Biol Cell 13, 3344-54.
- Lindhout, F.W. et al. (2019) EMBO J 38, e101345.
- Yang, X. and Tohda, C. (2024) Neurosci Lett 842, 137954.
- Pires, G. et al. (2019) Acta Neuropathol Commun 7, 195.
- Drummond, E. et al. (2017) Acta Neuropathol 133, 933-954.
- Weiner, S. et al. (2023) Alzheimers Dement 19, 4609-4618.
- Suda, T. et al. (2006) Cancer Sci 97, 411-9.
- Lin, S. et al. (2015) Dis Markers 2015, 230703.
- Xiao, L. et al. (2023) Sci Rep 13, 14922.
Alternate Names
KIAA0193; SCRN1; secernin 1; Secernin-1; SES1
限制使用
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For Research Use Only. Not for Use in Diagnostic Procedures.
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