Name: RPL22L1 (E9P6N) Rabbit Monoclonal Antibody
Price: 376.00 USD
Availability: InStock

Filter:

WB
IP

Product Specifications

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	15
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting
IP-Immunoprecipitation

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Immunoprecipitation	1:200

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

实验步骤

Specificity / Sensitivity

RPL22L1 (E9P6N) Rabbit Monoclonal Antibody recognizes endogenous levels of total RPL22L1 protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro9 of human RPL22L1 protein.

Background

RPL22 and RPL22L1 are highly related 60S ribosomal protein paralogs. They both function in protein synthesis and play distinct and sometimes antagonistic roles in hematopoietic stem cell development through p53 (1-3). RPL22 can directly regulate RPL22L1 expression by binding to an internal hairpin on the RPL22L1 mRNA. RPL22 has also been shown to interact with mRNAs for telomerase, histone H1, and EBER1, a noncoding RNA from the Epstein-Barr virus (EBV) (4-6). Both RPL22 and RPL22L1 have been shown to play roles in carcinogenesis. Inactivation of RPL22 can occur in acute lymphoblastic leukemias, which results in increased expression of Lin28B (2). Low expression of RPL22 has also been described in lung and gastric cancers (7,8). RPL22L1 has been implicated in prostate cancer, and its induction is associated with poor prognosis in colorectal cancer (9,10).

Alternate Names

60S ribosomal protein L22-like 1; Large ribosomal subunit protein eL22-like 1; MGC104449; Ribosomal protein eL22-like; ribosomal protein L22 like 1; ribosomal protein L22-like 1; RL22L; RPL22L1

Database Links

UniProt ID: Q6P5R6

Entrez-Gene Id: 200916

限制使用

除非 CST 的合法授书代表以书面形式书行明确同意，否书以下条款适用于 CST、其关书方或分书商提供的书品。任何书充本条款或与本条款不同的客书条款和条件，除非书 CST 的合法授书代表以书面形式书独接受，否书均被拒书，并且无效。

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For Research Use Only. Not for Use in Diagnostic Procedures.

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RPL22L1 (E9P6N) Rabbit Monoclonal Antibody #40259