Name: RBM9 (E7W6U) Rabbit Monoclonal Antibody
Price: 376.00 USD
Availability: InStock

Filter:

WB
IP

Product Specifications

REACTIVITY	H Mk
SENSITIVITY	Endogenous
MW (kDa)	50, 60
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting
IP-Immunoprecipitation

Species Cross-Reactivity Key:

H-Human
Mk-Monkey

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Immunoprecipitation	1:100

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

实验步骤

Specificity / Sensitivity

RBM9 (E7W6U) Rabbit Monoclonal Antibody recognizes endogenous levels of total RBM9 protein. This antibody detects multiple isoforms of RBM9.

Species Reactivity:

Human, Monkey

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala77 of human RBM9 protein.

Background

RBM9, also known as RBFOX2, is an RNA-binding protein involved in the regulation of tissue specific alternative splicing (1). RBM9 is widely expressed in many tissues throughout various developmental stages. Several isoforms of this protein are generated by variable use of multiple alternatively spliced internal exons and alternative splice sites (2-4). RBM9 is predominantly localized in the nucleus, where it regulates alternative pre-mRNA splicing. This factor was also identified to be a novel constituent of cytoplasmic stress granules (SGs), and its RNA binding activity is necessary for its localization into SGs (5). Notably, RBM9 dissociation from SGs suppresses cancer progression (6). The splicing-regulatory role of RBM9 has also been implicated as a tumor suppressor in pancreatic ductal adenocarcinoma (PDA) and could serve as a therapeutic approach for metastatic PDA (7).

Alternate Names

dJ106I20.3; Fox-1 homolog B; fox-1 homologue; Fox-2; FOX2; fxh; hexaribonucleotide binding protein 2; Hexaribonucleotide-binding protein 2; HNRBP2; HRNBP2; RBFOX2; RBM9; Repressor of tamoxifen transcriptional activity; RFOX2; RNA binding fox-1 homolog 2; RNA binding motif protein 9; RNA binding protein fox-1 homolog 2; RNA binding protein, fox-1 homolog 2; RNA-binding motif protein 9; RNA-binding protein 9; RTA

Database Links

UniProt ID: O43251

Entrez-Gene Id: 23543

限制使用

除非 CST 的合法授书代表以书面形式书行明确同意，否书以下条款适用于 CST、其关书方或分书商提供的书品。任何书充本条款或与本条款不同的客书条款和条件，除非书 CST 的合法授书代表以书面形式书独接受，否书均被拒书，并且无效。

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For Research Use Only. Not for Use in Diagnostic Procedures.

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RBM9 (E7W6U) Rabbit Monoclonal Antibody #37315