Rag Protein Antibody Sampler Kit

Inquiry Info. # 9778

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Product Information

Kit Usage Information

Protocols

2280: Western Blotting, Immunoprecipitation (Magnetic)
2983: Western Blotting, Immunoprecipitation (Magnetic), Immunohistochemistry (Paraffin), Immunofluorescence, Flow
4357: Western Blotting, Immunoprecipitation (Magnetic)
4470: Western Blotting
5466: Western Blotting, Immunoprecipitation (Agarose), Immunohistochemistry (Paraffin)
7074: Western Blotting
8150: Western Blotting, Immunoprecipitation (Magnetic)

Product Description

The Rag Protein Antibody Sampler Kit provides an economical means to evaluate the regulation of mTORC1 signaling by such proteins as Raptor, RagA, RagB, RagC, and RagD. The kit contains enough primary and secondary antibodies to perform four Western blot experiments per primary antibody.

Background

The mTORC1 kinase complex is a critical regulator of cell growth (1,2). Its activity is modulated by energy levels, growth factors, and amino acids via signaling through Akt, MAPK, and AMPK pathways (3,4). Recent studies found that the four related GTPases, RagA, RagB, RagC, and RagD, interact with raptor within the mTORC1 complex (1,2). These interactions are both necessary and sufficient for mTORC1 activation in response to amino acid signals (1,2).

Alternate Names

FIP; FIP-1; FIP1; mTOR; mTORC; Rag; Rag A; Rag B; Rag C; Rag D; RagA; ragab; RagB; RagC; ragcd; RagD; Raptor; Ras-related GTP-binding protein; rasraf; RRAG; TOR

Database Links

UniProt ID: P42345 , Q8N122 , Q9HB90 , Q7L523 , Q9NQL2 , Q5VZM2

Entrez-Gene Id: 2475 , 57521 , 64121 , 10670 , 58528 , 10325

限制使用

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For Research Use Only. Not for Use in Diagnostic Procedures.

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Rag Protein Antibody Sampler Kit #9778