Name: PRPF4 (F9Z1U) Rabbit Monoclonal Antibody
Price: 161.00 USD
Availability: InStock

Filter:

WB

Product Specifications

REACTIVITY	H M R Mk
SENSITIVITY	Endogenous
MW (kDa)	60
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human
M-Mouse
R-Rat
Mk-Monkey

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

实验步骤

Specificity / Sensitivity

PRPF4 (F9Z1U) Rabbit Monoclonal Antibody recognizes endogenous levels of total PRPF4 protein.

Species Reactivity:

Human, Mouse, Rat, Monkey

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala278 of human PRPF4 protein.

Background

PRPF4 is a U4/U6 snRNP-associated WD repeat-containing protein that is a critical regulator of the splicing process (1-3). PRPF4, PRPF3, and PPIH form a stable complex essential for proper formation and function of the U4/U6.U5 tri-snRNP (3,4). PRPF4 associates with kinetochores and can affect mitosis checkpoint control through MPS1, MAD1, and MAD2 (5). PRPF4 also has been shown to play a role in pluripotency and stem cell differentiation (6). Mutations in PRPF4 cause autosomal dominant retinitis pigmentosa (7,8). Furthermore, knockdown of PRPF4 has been shown to reduce colony formation and cell growth in breast cancer cells (9).

Alternate Names

hPrp4; HPRP4P; pre-mRNA processing factor 4; PRP4; PRP4 homolog; PRP4 pre-mRNA processing factor 4 homolog; PRP4 pre-mRNA processing factor 4 homolog (yeast); PRP4/STK/WD splicing factor; Prp4p; PRPF4; RP70; SNRNP60; U4/U6 small nuclear ribonucleoprotein Prp4; U4/U6 snRNP 60 kDa protein; WD splicing factor Prp4

Database Links

UniProt ID: O43172

Entrez-Gene Id: 9128

限制使用

除非 CST 的合法授书代表以书面形式书行明确同意，否书以下条款适用于 CST、其关书方或分书商提供的书品。任何书充本条款或与本条款不同的客书条款和条件，除非书 CST 的合法授书代表以书面形式书独接受，否书均被拒书，并且无效。

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For Research Use Only. Not for Use in Diagnostic Procedures.

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PRPF4 (F9Z1U) Rabbit Monoclonal Antibody #37095