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  3. PRPF3 (F8X1N) Rabbit Monoclonal Antibody
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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

PRPF3 (F8X1N) Rabbit Monoclonal Antibody #45889

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  • WB
  • IF

    Product Specifications

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 85
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IF-Immunofluorescence 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunofluorescence (Immunocytochemistry) 1:100

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    实验步骤

    Specificity / Sensitivity

    PRPF3 (F8X1N) Rabbit Monoclonal Antibody recognizes endogenous levels of total PRPF3 protein.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu672 of human PRPF3 protein.

    Background

    Pre-mRNA processing factor 3 (PRPF3) is a U4/U6 snRNP-associated protein that is a critical regulator of the splicing process (1-3). PRPF3, PRPF4, and PPIH form a stable complex essential for the proper formation and function of the U4/U6.U5 tri-snRNP (3). PRPF3 interacts with SPF30, which forms a bridge between tri-snRNP and U2AF35, a protein that recognizes 3’ splice sites (4). PRPF3 mutations cause autosomal dominant retinitis pigmentosa (5,6). Furthermore, PRPF3 has been identified as a potential oncogene in hepatocellular carcinoma (7).

    Alternate Names

    HPRP3; HPRP3P; pre-mRNA processing factor 3; Pre-mRNA-splicing factor 3; PRP3; PRP3 pre-mRNA processing factor 3 homolog; PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae); Prp3p; PRPF3; RP18; SNRNP90; U4/U6 small nuclear ribonucleoprotein Prp3; U4/U6 snRNP 90 kDa protein; U4/U6-associated RNA splicing factor

    Database Links

    UniProt ID: O43395


    Entrez-Gene Id: 9129


    限制使用

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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