PRDM16 (F3K9T) Rabbit Monoclonal Antibody #16212

PRDM16 is a transcription factor that is structurally characterized by a conserved N-terminal PRDI-BF1 and RIZ1 homology (PR) domain and a variable number of zinc fingers (1,2). The PR domain bears similarities to the catalytic suppressor of variegation 3–9, enhancer of zeste, and trithorax (SET) domain that is found in a group of histone methyltransferases (1,3). Indeed, PRDM16 has been shown to catalyze mono-methylation of histone 3 at lysine (H3K9me1) (4). Human PRDM16 encodes a protein with four isoforms with the most extensively studied isoforms being the full-length PRDM16 and the PR-lacking isoform that is generated by a transcript derived from an internal promoter (5). PRDM16 is involved in the regulation of various biological processes, including adipose biology and energy homeostasis. This protein is also expressed in hematopoietic stem cells (HSCs) and plays a key role in the establishment and maintenance of these cells (6,7). More recently, PRDM16 was shown to be a suppressor of lung adenocarcinoma metastasis, and its low expression predicted poor prognosis of lung adenocarcinoma patients (8).