Name: PNUTS (D8H5J) Rabbit Monoclonal Antibody
Price: 339.00 USD
Availability: InStock

Filter:

WB

Product Specifications

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	115
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

PNUTS (D8H5J) Rabbit Monoclonal Antibody recognizes endogenous levels of total PNUTS protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys244 of human PNUTS protein.

Background

Protein phosphatase-1 nuclear targeting subunit (PNUTS) is one of the key regulators of protein phosphatase 1 (PP1) in the nucleus (1). Via interaction with PP1, PNUTS plays an essential role in multiple cellular processes, including chromatin decondensation (2), DNA damage response (3), and cardiomyocyte apoptosis (4). Notably, PNUTS also regulates the activity of two key tumor suppressors, Rb and p53, through inhibition of PP1 mediated dephosphorylation (5-7). Research studies indicate that PNUTS also sequesters PTEN in the nucleus through direct interaction and inhibits its tumor suppressor function (8). PNUTS is ubiquitously expressed and elevated PNUTS expression is observed in various cancers such as esophageal carcinoma, squamous cell carcinoma, and prostate cancer (1,8).

Alternate Names

CAT53; FB19; HLA-C associated transcript 53; MHC class I region proline-rich protein CAT53; p99; Phosphatase 1 nuclear targeting subunit; phosphatase nuclear targeting subunit; PNUTS; PP1-binding protein of 114 kDa; PP1R10; PP1RA; PPP1R10; Protein FB19; protein phosphatase 1 regulatory subunit 10; protein phosphatase 1, regulatory (inhibitor) subunit 10; protein phosphatase 1, regulatory subunit 10; R111; Serine/threonine-protein phosphatase 1 regulatory subunit 10; testis tissue sperm-binding protein Li 67n

Database Links

UniProt ID: Q96QC0

Entrez-Gene Id: 5514

限制使用

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For Research Use Only. Not for Use in Diagnostic Procedures.

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PNUTS (D8H5J) Rabbit Monoclonal Antibody #80920