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  3. PCGF2 (F9G6A) Rabbit Monoclonal Antibody
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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

PCGF2 (F9G6A) Rabbit Monoclonal Antibody #16990

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  • WB
  • IP

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 50, 60
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:100

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    实验步骤

    Specificity / Sensitivity

    PCGF2 (F9G6A) Rabbit Monoclonal Antibody recognizes endogenous levels of total PCGF2 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly140 of human PCGF2 protein.

    Background

    Polycomb group RING finger homologs (PCGF1-6) are essential proteins for the assembly of the polycomb repressive complex 1 (PRC1) group of complexes. RING1A/B and a unique PCGF protein make up the catalytic core of PRC1 to ubiquitinate histone H2A. Differences in binding specificities give PRC1 complexes unique functions, depending on which PCGF is included (1-3). Polycomb group RING finger protein 2 (PCGF2), also known as Mel-18, is widely expressed in human tissues and primarily functions as a transcriptional repressor. This protein is broadly expressed in human tissues and has been implicated in numerous regulatory pathways that include cell proliferation and senescence, X chromosome inactivation, embryogenesis, hematopoiesis, and tumor suppression (4-10).

    Furthermore, this protein is known to harbor posttranslational modifications, including phosphorylation and ubiquitination, and is also reported to dimerize (11,12).

    Alternate Names

    DNA-binding protein Mel-18; MEL-18; MEL18; MGC10545; PCGF2; polycomb group ring finger 2; Polycomb group RING finger protein 2; RING finger protein 110; RNF110; TPFS; Zinc finger protein 144; ZNF144

    Database Links

    UniProt ID: P35227


    Entrez-Gene Id: 7703


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    For Research Use Only. Not for Use in Diagnostic Procedures.
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