|PARP (46D11) Rabbit mAb 9532
|H M R Mk
|AIF (D39D2) XP® Rabbit mAb 5318
|H M R Mk
|MIF (E8S8H) Rabbit mAb 75038
|H M R Hm
|Poly/Mono-ADP Ribose (E6F6A) Rabbit mAb 83732
|Anti-rabbit IgG, HRP-linked Antibody 7074
Monoclonal antibodies are produced by immunizing animals with synthetic peptides corresponding to residues surrounding Gly623 of human PARP-1, Ala520 of human AIF, and Tyr100 of human MIF protein, or with KLH modified on lysines with ADP ribose.
Parthanatos is a form of regulated cell death that follows a multistep cascade and is triggered by the accumulation of poly (ADP-ribose) (PAR). When PAR polymerase-1 (PARP-1) is overactivated under certain conditions, excessive PAR is produced and binds to apoptosis-inducing factor (AIF). As a result, AIF is released from the mitochondria and forms a complex with macrophage migration inhibitory factor (MIF). Subsequently, the AIF/MIF complex is translocated to the nucleus where MIF cleaves genomic DNA into large fragments, and cell death follows (1-3). Studies have found that parthanatos is involved in the pathogenesis of many diseases, particularly neurodegenerative disorders, such as Alzheimer's disease, Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS) (4-7).
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