Name: PARG (D4E6X) Rabbit Monoclonal Antibody
Price: 339.00 USD
Availability: InStock

Filter:

WB
IP

Product Specifications

REACTIVITY	H Mk
SENSITIVITY	Endogenous
MW (kDa)	130
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting
IP-Immunoprecipitation

Species Cross-Reactivity Key:

H-Human
Mk-Monkey

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Immunoprecipitation	1:100

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

PARG (D4E6X) Rabbit Monoclonal Antibody recognizes endogenous levels of total PARG protein. This antibody specifically recognizes PARG isoform 1 (UniProt #Q86W56-1) and does not recognize other PARG isoforms.

Species Reactivity:

Human, Monkey

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human PARG protein.

Background

Poly (ADP-ribose) glycohydrolase (PARG) is an enzyme that hydrolyzes poly (ADP-ribose) (PAR) formed by members of the PAR polymerase (PARP) enzyme family. Poly (ADP)-ribosylation is a post-translational modification that is catalyzed by PARP proteins. This modification involves polymerization of ADP-ribose from NAD⁺ to target proteins, such as histones and transcription factors, and plays a wide range of biological roles, including the response to DNA damage and transcriptional regulation (1,2). The mammalian PARG enzyme that catalyzes the removal of this modification exists as multiple isoforms. PARG isoforms 1-3 shuttle between the nucleus and cytoplasm and are responsible for most of the PARG activity. The smaller isoforms 4 and 5 reside in the cytoplasm (3-5). Research studies link altered PAR metabolism to inflammatory and autoimmune diseases, as well as neuronal degeneration (6-8). PARG inhibitors that increase PAR levels may sensitize cells to cancer treatments (e.g., cisplatin) and may help in the development of cancer therapies (9).

Alternate Names

FLJ60456; mitochondrial poly(ADP-ribose) glycohydrolase; PARG; PARG99; poly (ADP-ribose) glycohydrolase; Poly(ADP-ribose) glycohydrolase; poly(ADP-ribose) glycohydrolase 60 kDa isoform

Database Links

UniProt ID: Q86W56

Entrez-Gene Id: 8505

限制使用

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For Research Use Only. Not for Use in Diagnostic Procedures.

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PARG (D4E6X) Rabbit Monoclonal Antibody #66564