Nipah/Hendra virus Nucleocapsid (F5N9K) Rabbit Monoclonal Antibody #32952

Nipah virus (NiV) and Hendra virus (HeV) are highly pathogenic zoonotic paramyxoviruses belonging to the Henipavirus genus. They both possess a non-segmented, negative-sense single-stranded RNA genome, which is tightly encapsidated by the nucleocapsid (N) protein to form a helical ribonucleoprotein (RNP) complex, the fundamental unit for viral RNA synthesis and genome protection (1). The N protein, which is largely conserved between the two viruses, is a major structural component and a key player in its replication cycle. The primary function of the NiV/HeV N protein is to encapsidate viral genomic and antigenomic RNA. Encapsidation is essential for genome protection, template assembly for RNA synthesis, and nucleocapsid assembly. It also interacts with other viral proteins, such as the viral phosphoprotein (P), which acts as a chaperone for newly synthesized N protein subunits (2). Understanding the structure and function of the NiV and HeV N protein is critical for developing targeted antiviral therapies against this and other highly pathogenic viruses in the Paramyxoviridae family (3).