Name: NCR3/NKp30 (F3O3Q) Rabbit Monoclonal Antibody
Price: 155.00 USD
Availability: InStock

Filter:

WB

Product Specifications

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	25-50
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

NCR3/NKp30 (F3O3Q) Rabbit Monoclonal Antibody recognizes endogenous levels of total NCR3/NKp30 protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu86 of human NCR3/NKp30 protein.

Background

The family of natural cytotoxicity receptors (NCRs) contains NCR1 (NKp46/CD335), NCR2 (NKp44/CD336), and NCR3 (NKp30/CD337). They are single-pass type I transmembrane proteins belonging to the immunoglobulin (Ig) superfamily. Various pathogen-derived and host-encoded molecules have been identified as ligands for the NCRs. They were originally identified by their ability to evoke the cytotoxicity of natural killer (NK) cells toward tumor cells in vitro, and animal models have demonstrated that NCRs play a role in vivo in tumor surveillance, viral infection, and pregnancy (1-5).

NCR3/NKp30 is constitutively expressed in NK cells and at low levels in subpopulations of CD8⁺ cytotoxic T lymphocytes and γδ T cells (6, 7). NCR3/NKp30 is being investigated as a target for immunotherapies due to its role in mediating NK cell antitumor effects (8).

Alternate Names

1C7; Activating natural killer receptor p30; activating NK-A1 receptor; CD337; LY117; lymphocyte antigen 117; MALS; Natural cytotoxicity triggering receptor 3; Natural killer cell p30-related protein; NCR3; NCTR3; NK-p30; NKp30

Database Links

UniProt ID: O14931

Entrez-Gene Id: 259197

限制使用

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For Research Use Only. Not for Use in Diagnostic Procedures.

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NCR3/NKp30 (F3O3Q) Rabbit Monoclonal Antibody #87214