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  3. Melanotransferrin (F3W8H) Rabbit Monoclonal Antibody
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Melanotransferrin (F3W8H) Rabbit Monoclonal Antibody #20173

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  • WB
  • IP

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 97
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Simple Western™ 1:10 - 1:50
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    实验步骤

    Specificity / Sensitivity

    Melanotransferrin (F3W8H) Rabbit Monoclonal Antibody recognizes endogenous levels of total melanotransferrin protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly668 of human melanotransferrin protein.

    Background

    Melanotransferrin, also known as MTF, MFI2, CD228, or p97, is a membrane-bound glycoprotein that is commonly associated with melanoma (1). Melanotransferrin shares structural similarity and iron-binding properties with the protein transferrin, although it does not appear to be involved with iron transport (2-4). Melanotransferrin is expressed at low levels in normal tissue but has elevated expression in melanoma (5,6). The exact biological function of melanotransferrin in melanoma is not yet fully understood, but it is believed to play a role in cell proliferation and invasion (7). Upregulation of melanotransferrin has also been observed in other forms of cancer, such as lung, colorectal, gastric, and oral squamous cell carcinoma (OSCC) (8-11).

    Alternate Names

    antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5; CD228; FLJ38863; MAP97; Melanoma-associated antigen p97; melanoma-associated antigen p97, isoform 2; Melanotransferrin; MELTF; membrane-bound transferrin-like protein; MFI2; MGC4856; MTf; MTF1; TRFM

    Database Links

    UniProt ID: P08582


    Entrez-Gene Id: 4241


    限制使用

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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