MAZ (F3I2I) Rabbit Monoclonal Antibody #90940

The Myc-associated zinc finger protein (MAZ) is a transcription factor (TF) with four annotated isoforms and is widely expressed in most human tissues. This protein was independently identified as a regulator of MYC gene expression (1), activator of an insulin promoter (2), and modulator of serum amyloid A (3). Previous studies have shown that MAZ plays important roles in regulation of a wide variety of genes (4-6). Specifically, MAZ plays a dual role in regulating transcription initiation and termination processes. More recently, genome-wide screens have identified MAZ as a requirement for CTCF-mediated insulation (7). MAZ has also been shown to be highly expressed in malignant tumors and to promote tumorigenesis by directly binding to target gene promoters and cooperating with other TFs (8-13).