MAST1 (E4K5G) Rabbit Monoclonal Antibody #38959

MAST1 is a member of the microtubule-associated serine/threonine kinase (MAST) family of protein kinases. It possesses a serine/threonine kinase domain and a PDZ domain, the latter being important for its function as a scaffold molecule linking the dystrophin and utrophin complex with microfilaments (1,2). Expression of the gene encoding MAST1 is upregulated following glucocorticoid receptor activation, while MAST1 protein expression levels can be maintained by complex formation with HSP90B, protecting MAST1 from degradation (3,4). MAST1 gene rearrangements have been found in breast cancers, where MAST1 was reported to promote cell proliferation and tumor growth (5). MAST1 was also identified as a critical factor involved in the development of cisplatin resistance, via binding and phosphorylation of MEK1 that led to inhibition of apoptosis (6). MAST1 also plays an important role in neuron development and function (7). Numerous mutations in the gene encoding MAST1 are reported to associate with neural disorders, including mega-corpus-callosum syndrome, congenital bilateral perisylvian syndrome (CBPS), and intellectual disability (ID) (8-10).