LTA4H (F9F5O) Rabbit Monoclonal Antibody #38877

Leukotrienes (LTs) are a group of biologically active lipid mediators (LTA4, LTB4, LTC4, LTD4, and LTE4), which are secreted from multiple cell types and play a critical role in recruiting leukocytes and other immune cells to sites of inflammation in the periphery. The enzyme leukotriene A4 hydrolase (LTA4H) classically functions intracellularly, primarily within myeloid cells, to convert LTA4 into pro-inflammatory lipid mediator LTB4 (1). But LTA4H is a bifunctional zinc metalloenzyme that comprises both epoxide hydrolase and aminopeptidase activity, exerted by two overlapping catalytic sites (2). The aminopeptidase function of LTA4H is responsible for the tripeptide Pro-Gly-Pro (PGP) degradation. This suggests that LTA4H may have two opposing roles in the inflammation regulation: on the one hand, LTA4H is responsible for the biosynthesis of the pro-inflammatory, neutrophil chemotactic lipid mediator LTB4, and on the other hand, it degrades and inactivates the chemotactic tripeptide PGP (3). More recently, LTA4H expression has been found in healthy mouse neurons, and inhibition of LTA4H in aged mice improved hippocampal-dependent memory. In addition, LTA4H plasma levels are increased in both aging and Alzheimer’s disease and correlated with cognitive impairment (4).