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  3. LRBA Antibody

LRBA Antibody #86622

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  • WB
  • IP

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 320
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    实验步骤

    Specificity / Sensitivity

    LRBA Antibody recognizes endogenous levels of total LRBA protein. This antibody detects a 130 kDa band of unknown origin in some cell lines.

    Species Reactivity:

    Human

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human LRBA protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    LRBA (lipopolysaccharide responsive beige-like anchor protein) is a 300 kDa intracellular protein that is a member of the PH-BEACH-WD40 protein family (1-3). Its BEACH domain contains an A-kinase anchoring protein (AKAP) motif, known to have an affinity for signaling enzymes (1,3). LRBA has been found to be overexpressed in several different cancers, such as renal, pancreas, colorectal, and lung (2). LRBA deficiency, caused by various mutations, can cause common variable immune deficiency (CVID) as well as other immune dysregulations (3,5). LRBA plays an immunoregulatory role to CTLA-4, protecting it from being degraded within lysosomes (4,6). In LRBA deficiency, CTLA-4 is synthesized normally, but is not delivered to Rab GTPase recycling compartments, instead resulting in enhanced lysosome degradation (4,6,7).

    Alternate Names

    Beige-like protein; BGL; CDC4-like protein; CDC4L; cell division cycle 4-like; CVID8; DKFZp686A09128; DKFZp686K03100; DKFZp686P2258; FLJ16600; FLJ25686; LAB300; LBA; Lipopolysaccharide-responsive and beige-like anchor protein; LPS responsive beige-like anchor protein; LPS-responsive vesicle trafficking, beach and anchor containing; LRBA; MGC72098; vesicle trafficking, beach and anchor containing

    Database Links

    UniProt ID: P50851


    Entrez-Gene Id: 987


    限制使用

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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