Kinectin 1 Antibody

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WB

Inquiry Info. # 8772

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Product Specifications

REACTIVITY	H Mk Dg
SENSITIVITY	Endogenous
MW (kDa)	160
SOURCE	Rabbit

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human
Mk-Monkey
Dg-Dog

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

实验步骤

Specificity / Sensitivity

Kinectin 1 Antibody recognizes endogenous levels of total kinectin 1 protein.

Species Reactivity:

Human, Monkey, Dog

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human kinectin 1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Kinectin 1 (KTN1) is an endoplasmic reticulum (ER)-enriched integral membrane protein that may be involved in the formation of ER sheets (reviewed in 1). Kinectin 1 binds the microtubule motor protein kinesin and acts as a membrane anchor for kinesin-based organelle trafficking (2). The interaction of kinesin with kinectin 1 has been shown to affect ER-supported focal adhesion assembly (3). Kinectin 1 has also been implicated in translation elongation, as an anchor for the elongation factor complex to the ER (4,5). Research investigators have shown that kinectin 1 expression is altered in multiple human pathologies, including breast cancer (6), hepatocellular carcinoma (HCC) (7), Parkinson's disease (8), and the autoimmune syndrome Behçet's disease (BD) (9,10).

Alternate Names

CG-1 antigen; CG1; KIAA0004; Kinectin; kinectin 1; kinectin 1 (kinesin receptor); Kinesin receptor; KNT; KTN1; MGC133337; MU-RMS-40.19

Database Links

UniProt ID: Q86UP2

Entrez-Gene Id: 3895

限制使用

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For Research Use Only. Not for Use in Diagnostic Procedures.

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Kinectin 1 Antibody #8772