Name: KIF5A (F2W1W) Rabbit Monoclonal Antibody
Price: 376.00 USD
Availability: InStock

Filter:

WB

Product Specifications

REACTIVITY	H M R
SENSITIVITY	Endogenous
MW (kDa)	125
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human
M-Mouse
R-Rat

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

实验步骤

Specificity / Sensitivity

KIF5A (F2W1W) Rabbit Monoclonal Antibody recognizes endogenous levels of total KIF5A protein.

Species Reactivity:

Human, Mouse, Rat

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro817 of human KIF5A protein.

Background

Kinesin superfamily proteins (KIFs) are molecular motors that drive directional, microtubule-dependent intracellular transport of membrane-bound organelles and other macromolecules (e.g., proteins, nucleic acids). The intracellular transport functions of KIFs are fundamentally important for various cellular functions, including mitotic and meiotic division, motility/migration, hormone and neurotransmitter release, and differentiation (1-4). Disruptions to KIF-mediated intracellular transport have been linked with various pathologies, ranging from tumorigenesis to defects in higher-order brain functions such as learning and memory (4-6).

KIF5 consists of three family members: KIF5A, KIF5B, and KIF5C (7). KIF5A and KIF5C are specifically expressed in neurons, whereas KIF5B is expressed ubiquitously (7-10). KIF5A has recently also been found to be expressed in astrocyte processes and mutations of the protein have been linked to amyotrophic lateral sclerosis (ALS) (11-13).

Alternate Names

ALS25; D12S1889; KIF5A; KIF5A variant protein; kinesin family member 5A; Kinesin heavy chain isoform 5A; Kinesin heavy chain neuron-specific 1; kinesin, heavy chain, neuron-specific; MY050; NEIMY; Neuronal kinesin heavy chain; NKHC; NKHC1; SPG10

Database Links

UniProt ID: Q12840

Entrez-Gene Id: 3798

限制使用

除非 CST 的合法授书代表以书面形式书行明确同意，否书以下条款适用于 CST、其关书方或分书商提供的书品。任何书充本条款或与本条款不同的客书条款和条件，除非书 CST 的合法授书代表以书面形式书独接受，否书均被拒书，并且无效。

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For Research Use Only. Not for Use in Diagnostic Procedures.

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KIF5A (F2W1W) Rabbit Monoclonal Antibody #92872