Name: INO80 (F2I3E) Rabbit Monoclonal Antibody
Price: 161.00 USD
Availability: InStock

Filter:

WB

Product Specifications

REACTIVITY	H M R Mk
SENSITIVITY	Endogenous
MW (kDa)	280
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human
M-Mouse
R-Rat
Mk-Monkey

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Simple Western™	1:10 - 1:50

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

实验步骤

Specificity / Sensitivity

INO80 (F2I3E) Rabbit Monoclonal Antibody recognizes endogenous levels of total INO80 protein. This antibody detects bands of unknown origin at 145, 55, and 50 kDa.

Species Reactivity:

Human, Mouse, Rat, Monkey

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly1547 of human INO80 protein.

Background

The INO80 complex is an ATP-dependent chromatin remodeling complex critical for many functions, including transcriptional regulation and DNA repair. INO80 is a large multi-subunit complex consisting of the key ATPase INO80 along with RUVBL1, RUVBL2, ARP4/5/8, and others (1-3). INO80 prefers binding to hexasomes and can facilitate the exchange of H2A.Z/H2B dimers with H2A/H2B (4-6). The INO80 complex is recruited to double-strand breaks (DSBs) through interaction between gamma-H2AX and complex member NHP10 (7,8). INO80 also plays an important role in transcription as it is required for proper pausing of RNA polymerase II (9).

Alternate Names

Chromatin-remodeling ATPase INO80; DNA helicase INO80; DNA helicase-related INO80 complex homolog 1; DNA helicase-related protein INO80; hINO80; homolog of yeast INO80; INO80; INO80 complex ATPase subunit; INO80 complex homolog 1; INO80 complex subunit A; INO80 homolog (S. cerevisiae); INO80A; INOC1; KIAA1259; Putative DNA helicase INO80 complex homolog 1

Database Links

UniProt ID: Q9ULG1

Entrez-Gene Id: 54617

限制使用

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For Research Use Only. Not for Use in Diagnostic Procedures.

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INO80 (F2I3E) Rabbit Monoclonal Antibody #73828