IL1F10 (F5U1T) Rabbit Monoclonal Antibody #60507

The interleukin-1 (IL-1) family of cytokines is critical in regulating innate and adaptive immune responses. The IL-1 family consists of receptor agonists and antagonists that have either pro- or anti-inflammatory roles, respectively (1-4). Interleukin 1 family member 10 (IL1F10), also known as IL-38, is a member of the IL-1 family that was originally shown to suppress inflammatory reactions in human cell lines and mouse models (2,3). IL1F10 is expressed in the heart, tonsil, skin, thymus, placenta, and particularly in keratinocytes and B cells (5). IL1F10 can induce a general anti-inflammatory program in several cell types, such as epithelial cells, dendritic cells (DCs), myeloid cells, Th17 cells, and regulatory T cells (Tregs) (3,5). Elevated IL1F10 expression in immune cells is indicative of its role in modulating immune cell function, and its expression in keratinocytes and epithelial cells suggests a function in maintaining immunological stability at sites of infection or environmental exposure. Recent work has focused on the role of dysregulated IL1F10 in cancer and autoimmunity (3,4,6,8). In mouse models, exogenous IL1F10 had a protective effect against the development of rheumatoid arthritis (RA), whereas its depletion worsened the disease in vivo (7). Aberrant expression of IL1F10 has been shown in several cancers, including colorectal, lung, and prostate cancers, making it a potential chemotherapeutic target (8).