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IL-2R gamma (E1V1O) Rabbit Monoclonal Antibody

IL-2R gamma (E1V1O) Rabbit Monoclonal Antibody #49622

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Product Specifications

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	60-80
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting
IF-Immunofluorescence
F-Flow Cytometry

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Immunofluorescence (Immunocytochemistry)	1:100 - 1:200
Flow Cytometry (Fixed/Permeabilized)	1:50 - 1:100
Flow Cytometry (Live)	1:50 - 1:100

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

实验步骤

Specificity / Sensitivity

IL-2R gamma (E1V1O) Rabbit Monoclonal Antibody recognizes endogenous levels of total IL-2Rγ protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the extracellular domain of human IL-2Rγ protein.

Background

IL-2Rγ (Cytokine receptor common subunit gamma, γc) is part of the interleukin-2 (IL-2) receptor, comprised of alpha, beta, and gamma chains (1-6). The gamma chain is required for the formation of high- and intermediate-affinity receptors, which consist of alpha beta gamma heterotrimers and beta gamma heterodimers (1). IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 all share the same common gamma chain, which was originally discovered as the gamma chain of the IL-2 receptor (3-6). The γ chain family of cytokines contribute to lymphocyte homeostasis by controlling aspects of lymphocyte development, growth, differentiation, and survival (5,6). In humans, a mutation in IL-2Rγ results in X-linked severe combined immunodeficiency (XSCID), which is a disease characterized by the absence of T and NK cells, with nonfunctional B cells (2).

Alternate Names

CD132; CD132 antigen; CIDX; common cytokine receptor gamma chain; common gamma-chain; Cytokine receptor common subunit gamma; gamma(c); gammaC; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG; IL2RG; IMD4; interleukin 2 receptor subunit gamma; interleukin 2 receptor, gamma; interleukin 2 receptor, gamma (severe combined immunodeficiency); Interleukin-2 receptor subunit gamma; nonfunctional common cytokine receptor gamma chain; p64; SCIDX; SCIDX1

Database Links

UniProt ID: P31785

Entrez-Gene Id: 3561

限制使用

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For Research Use Only. Not for Use in Diagnostic Procedures.

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