Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
IL-21R (F1O7J) Rabbit Monoclonal Antibody #50489
Filter:
- WB
- F
Product Specifications
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 90, 30 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- F-Flow Cytometry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Flow Cytometry (Fixed/Permeabilized) | 1:6400 |
| Flow Cytometry (Live) | 1:50 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
实验步骤
Specificity / Sensitivity
IL-21R (F1O7J) Rabbit Monoclonal Antibody recognizes endogenous levels of total IL-21R protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human IL-21R protein.
Background
Interleukin-21 receptor (IL-21R) is a type I cytokine receptor that forms a heterodimer with the common gamma chain (γc), also known as CD132 (1,2). Upon binding its ligand, IL-21, IL-21R activates downstream targets including Stat1, Stat3, PI3K, and ERK1/2 (2,3). IL-21R is expressed on a variety of lymphoid and myeloid cells, and its expression on T cells can be induced by T cell receptor activation (4-6). IL-21R plays an important role in the differentiation process of several immune subsets, such as follicular helper T cells, Th17 cells, and plasma cells, and helps to activate NK cells (7-10). IL-21R has been implicated in several inflammatory diseases, including Crohn's disease, systemic lupus erythematosus, and rheumatoid arthritis. Hyperactivation of IL-21R signaling drives inflammation (11-14).
- Spolski, R. and Leonard, W.J. (2014) Nat Rev Drug Discov 13, 379-95.
- Abhiraman, G.C. et al. (2023) Cell Rep 42, 112657.
- Fuqua, C.F. et al. (2008) Cytokine 44, 101-7.
- Akamatsu, N. et al. (2007) Cancer Lett 256, 196-206.
- Wu, Z. et al. (2005) Mol Cell Biol 25, 9741-52.
- Vallières, F. and Girard, D. (2013) J Immunol 190, 2904-12.
- Vogelzang, A. et al. (2008) Immunity 29, 127-37.
- Koh, C.H. et al. (2024) Immune Netw 24, e2.
- Moens, L. and Tangye, S.G. (2014) Front Immunol 5, 65.
- Skak, K. et al. (2008) Immunology 123, 575-83.
- Holm, T.L. et al. (2018) Gastroenterol Res Pract 2018, 5962624.
- McPhee, C.G. et al. (2013) J Immunol 191, 4581-8.
- Ueno, M. et al. (2024) RMD Open 10, e004567. doi: 10.1136/rmdopen-2024-004567.
- Chen, Q. et al. (2025) Immunol Invest 54, 1421-1444.
Alternate Names
CD360; IL-21 receptor; IL-21R; IL21R; IMD56; interleukin 21 receptor; Interleukin-21 receptor; NILR; Novel interleukin receptor; UNQ3121/PRO10273
限制使用
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For Research Use Only. Not for Use in Diagnostic Procedures.
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