Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
ICAM-5 (F6E2B) Rabbit Monoclonal Antibody #19394
Filter:
- WB
Product Specifications
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 140, 100 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Simple Western™ | 1:10 - 1:50 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
实验步骤
Specificity / Sensitivity
ICAM-5 (F6E2B) Rabbit Monoclonal Antibody recognizes endogenous levels of total ICAM-5 and sICAM-5 protein. This antibody detects a 70 kDa protein of unknown identity in some cell lines.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro40 of human ICAM-5 protein.
Background
Intercellular adhesion molecule-5 (ICAM-5), also known as telencephalin, is a type I membrane glycoprotein expressed on the surface of telencephalic neurons in the brain that plays a role in neuronal adhesion, signal transmission, and neurite outgrowth (1). ICAM-5 contains nine immunoglobulin-like domains in its extracellular region, which interact with integrins and ERM-family proteins, facilitating the formation of functional synapses and dendritic filopodia, respectively (2,3). This extracellular region has also been shown to be cleaved, forming a soluble ICAM-5 fragment implicated in the immune system, potentially playing a neuroprotective role in neurodegeneration (4-6).
Alternate Names
ICAM-5; ICAM5; Intercellular adhesion molecule 5; intercellular adhesion molecule 5, telencephalin; Telencephalin; TLCN; TLN
限制使用
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For Research Use Only. Not for Use in Diagnostic Procedures.
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