Name: hnRNP E2/PCBP2 (D1S5E) Rabbit Monoclonal Antibody
Price: 339.00 USD
Availability: InStock

Filter:

WB

Product Specifications

REACTIVITY	H M R
SENSITIVITY	Endogenous
MW (kDa)	35-45
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human
M-Mouse
R-Rat

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

hnRNP E2/PCBP2 (D1S5E) Rabbit Monoclonal Antibody recognizes endogenous levels of total hnRNP E2/PCBP2 protein.

Species Reactivity:

Human, Mouse, Rat

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu243 of human hnRNP E2/PCBP2 protein.

Background

PCBP2 (also known as hnRNP E2) is an RNA-binding protein that interacts in a sequence-specific fashion with single-stranded poly (rC). Through their poly(rC)-binding ability, PCBPs regulate mRNA stability and translation (1,2). PCBP2 is an iron chaperone; it delivers iron to ferritin for storage and mediates metalation of certain iron-containing proteins (3-5). PCBP2 interacts with the iron importer DMT1 (divalent metal transporter 1) and the iron exporter FPN1 (ferroportin 1) and regulates their activities (6,7). PCBP2 is induced by viral infection and targets MAVS for polyubiquitination and degradation (8-10). Recent reports demonstrate that it is involved in Hippo signaling, miRNA processing, immune suppression, and cancer (11-15) .

Alternate Names

Alpha-CP2; epididymis secretory sperm binding protein; Heterogeneous nuclear ribonucleoprotein E2; heterogenous nuclear ribonucleoprotein E2; hnRNP E2; hnRNP-E2; HNRNPE2; HNRPE2; MGC110998; PCBP2; poly(rC) binding protein 2; Poly(rC)-binding protein 2

Database Links

UniProt ID: Q15366

Entrez-Gene Id: 5094

限制使用

除非 CST 的合法授书代表以书面形式书行明确同意，否书以下条款适用于 CST、其关书方或分书商提供的书品。任何书充本条款或与本条款不同的客书条款和条件，除非书 CST 的合法授书代表以书面形式书独接受，否书均被拒书，并且无效。

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For Research Use Only. Not for Use in Diagnostic Procedures.

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hnRNP E2/PCBP2 (D1S5E) Rabbit Monoclonal Antibody #83017