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  3. HAPLN1 (F2Q6U) Rabbit Monoclonal Antibody
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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

HAPLN1 (F2Q6U) Rabbit Monoclonal Antibody #16514

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  • WB

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 50, 46
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    实验步骤

    Specificity / Sensitivity

    HAPLN1 (F2Q6U) Rabbit Monoclonal Antibody recognizes endogenous levels of total HAPLN1 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to human HAPLN1 protein.

    Background

    Hyaluronan and proteoglycan link protein 1 (HAPLN1) is a critical component of the extracellular matrix (ECM), functioning by cross-linking hyaluronic acid (HA) and various proteoglycans (1). The protein promotes the formation of aggregate structural complexes within the ECM, which are essential for cartilage formation and neocortex folding during development (2,3). Age dependent loss of HAPLN1 increases lymphatic and vascular permeability (4,5). Additionally, HAPLN1 protects cell-surface TGF-beta receptors, thereby maintaining TGF-beta signaling, contributing to the rejuvenation of aged skin and the mitigation of pulmonary emphysema (6,7). While increased expression of HAPLN1 is linked to cancer invasion, metastasis (8-10), therapeutic drug resistance (11), and inflammatory arthritis (12,13), knockdown of HAPLN1 has been shown to inhibit the development of heart failure by activating the PKA signaling pathway (14,15).

    Alternate Names

    Cartilage link protein; cartilage linking protein 1; Cartilage-link protein; Cartilage-linking protein 1; CRT1; CRTL1; HAPLN1; HPLN1; Hyaluronan and proteoglycan link protein 1; Proteoglycan link protein

    Database Links

    UniProt ID: P10915


    Entrez-Gene Id: 1404


    限制使用

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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