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  3. GIMAP5 Antibody

GIMAP5 Antibody #14108

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  • WB
  • IP

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 30,32
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    实验步骤

    Specificity / Sensitivity

    GIMAP5 Antibody recognizes endogenous levels of total GIMAP5 protein. This antibody also recognizes proteins of unknown origin at 12 kDa and 50 kDa.

    Species Reactivity:

    Human

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human GIMAP5 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    GTPase immune-associated proteins (GIMAP), also known as immune-associated nucleotide-binding (IAN) proteins, are evolutionarily conserved GTP-binding proteins involved in lymphocyte development, inflammation, and autoimmune diseases (reviewed in 1,2). Human GTPase IMAP family member 5 (GIMAP5, hIan5) is the homolog of the rat Ian4 protein that is mutated in severe cases of T-cell lymphopenia and insulin-dependent diabetes in Biobreeding diabetes-prone (BB-DP) rats (3,4). GIMAP5 protein is preferentially expressed in CD4- and CD8-positive T-cells as well as B-cell lymphomas (4). Research studies using GIMAP5-deficient mice show that GIMAP5 protein is critical for survival of peripheral T-cells, hematopoietic stem cells, and progenitor cells (5-7). Additional studies indicate that GIMAP5 deficiency leads to a loss of immunological tolerance (8). Polymorphisms in the human GIMAP5 gene are associated with systemic lupus erythematosus and type I diabetes (9-11). Potential mechanisms for GIMAP5 control of cell survival include regulation of Bcl-2 family proteins, mitochondrial integrity, lysosomal function, and calcium regulation (5,7, 11-14).

    Alternate Names

    FLJ11296; GIMA5; GIMAP5; GTPase IMAP family member 5; GTPase, IMAP family member 5; hIAN5; HIMAP3; IAN-5; IAN4; IAN4L1; IAN5; IMAP3; immune associated nucleotide 4 like 1; Immune-associated nucleotide-binding protein 5; immunity associated protein 3; Immunity-associated nucleotide 4-like 1 protein; Immunity-associated nucleotide 5 protein; Immunity-associated protein 3; inhibitor of radiation- and OA-induced apoptosis, Irod/Ian5; IROD

    Database Links

    UniProt ID: Q96F15


    Entrez-Gene Id: 55340


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    For Research Use Only. Not for Use in Diagnostic Procedures.
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